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Citations 5. References HSV type 2 HSV-2 causes genital diseases and neonatal infections through a maternal genital tract to the newborn Pellet and Roizman, Genital herpes caused by HSV-2 is one of the most important sexually transmitted diseases Bystrick? Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells.
Full-text available. Mar Acta Virol. In addition, it is known that nectin-2 is also functional as a receptor for HSV-2, although the binding to the gD is weak.
To examine an antiviral potential of a soluble form of human nectin-2 hNectin-2Ig , transfected Vero cells expressing the entire ectodomain of nectin-2 fused to the Fc portion of human IgG were established. Competitive ELISA demonstrated that accumulation of hNectin-2Ig in transfected cells increased significantly in a cell culture time dependent manner. Viral growth of several HSV-2 strains was significantly inhibited in the transfected cells that were cultured for 72 hr compared with control Vero cells, but not in cells that were cultured for 24 hr.